اثیرعصاره اتیل استاتی گیاه کلپوره بر میزان مصرف انرژی و پارامترهای چاقی در موش‌های صحرایی تغذیه شده با جیره غنی از سوکروز

  Introduction: Excessive caloric intake as a result of carbohydrate over feeding is the main cause of obesity. Recently, more attention has been given to the influence of herbal medicines for prevention and treatment of obesity. Teucrium polium (Calpoure) has been hypoglycemic, hypolipidemic, and antioxidant effects. At present study, the effect of T. polium ethylacetate extract that known as hepatoprotective and antioxidant agent has been investigated on obesity parameters sucrose-induced rats.   Materials: In this Experimental study, 30 adult male Wistar rats weighting 180 20 g were divided into 5 groups. Four groups obtained sucrose 50% in drinking water for 10 weeks. After 8th week, 3 randomly selected groups were treated with ethylacetate extract of T. polium for 50, 100 and 200 mg/kg. Sham animal group was fed using normal rat chow. After ten weeks, animals were euthanized and physical parameters have also been evaluated.   Result: The results have been shown that in control group food intake and energy consumption in comparison with the other groups, increased and decreased respectively. Sham animal group in comparison with the other groups, the weight of heart, body and abdominal fat pad, also leptin particularly were significantly increased. On the other side, it has been shown that the using T. polium ethylacetate extract significantly decreased the weight of heart, body, abdominal fat pad and Blood levels Leptin in a relatively dose-dependent way   Conclusion: This study showed that the using of T. polium ethylacetate extract with dose of 100 and 200 mg /kg for 2 weeks cause reduction in obesity parameters